Tehran University of Medical Sciences
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Comparison of desensitizing efficacy of an Iranian dentifrice and a commercially available dentifrice: a randomized double-blinded controlled clinical trial.

Authors: Moslemi N, Johari M, Akhoundi MS, Zare H, Shamshiri AR, Khorshidian A
Keywords: Clinical Trial, Dentin Hypersensitivity, Potassium Nitrate, Toothpaste
(J Dent (Tehran, Vol.10, No.4, 2013,Page:351-7



The aim of this randomized controlled clinical trial was to investigate the effect of a new Iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.


Fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. The participants were randomly given one of the two toothpastes; Iranian (antihypersensitive Pooneh) or commercially available (fresh mint Sensodyne) toothpaste. Visual analogue scales (VASs) indicating the intensity of tooth hypersensitivity responding to tactile, airblast and cold-water stimuli were examined at baseline and weeks 2, 4, 12 and 24.


Overall, VAS scores for tactile, airblast, and cold-water tests significantly reduced compared with the baseline in both groups (all P values <0.001). However, there was no significant difference between the two groups regarding the measured parameters.


This study demonstrated that the Iranian dentifrice (antihypersensitive Pooneh) was as effective as the c