Tehran University of Medical Sciences
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Sima Sadrai

Contact Information
www.tums.ac.ir\sadrai
Tel: 02166959054
Fax: 0098 21 66461178
Address: Tehran University of Medical Sciences, School of Pharmacy,P.O.Box 14155/6451
Academic Rank
Associate Professor
School
Pharmacy
Pharmaceutics
Research Center
Pharmaceutical Sciences Research Center
About
CV last edited on: 2015/11/07

1.

Pharm D


School of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran, 1987
Thesis Title:Synthesis of 2-nitroimidazole-1,3,4-thiadiazoles and their antimicrobial activity
2.

Ph.D


Depart. of Pharmaceutics, School of Pharmacy, Tehran Univ. of Me, Tehran, Iran, 1997
Thesis Title:Population pharmacokinetics study of theophylline in Iranian patients Homeopathy 1994-1996, A course in Homeopathy
3.

Fellowship


Uppsala University, Sweden, 1998-1999
Thesis Title:Pharmacokinetic-pharmacodynamic Modelling
Supervisor:Professor Mats Karlsson
4.

-


Homeopathy , 1994-1996
1.

Persian


Speaking: Native, Reading: Native, Writing: Native
2.

English


Speaking: Medium, Reading: Good, Writing: Medium
3.

Germany


Speaking: Good, Reading: Good, Writing: Good
4.

Arabic


Speaking: Medium, Reading: Good, Writing: Medium

Pharm D

1.

Pharmaceutical Chemistry


1987-1990 Pharm D.
2.

Biopharmaceutics and Pharmacokinetics


1990 Pharm D.
3.

General Chemistry


1987- 1990 Pharm D.
4.

Physical Pharmacy


1990 Pharm D.
5.

Complementary and Alternative Medicine


Pharm D.

Ph.D

1.

Pharmacokinetics


1998 Ph.D.
2.

Research Methodology


Ph.D.
3.

Complementary Medicine


Ph.D.
4.

Biostatistic


1394 Ph.D.
1.

Complementary medicine


Status: Completed,
2.

In vitro-in vivo correlation modeling of Indomethcin, Rifampine and Diclophenac, etc


Status: Completed,
3.

Methodological methods in population pharmacokinetic model building


Status: Completed,
4.

The Bioavailability and Pharmacokinetic Study of Ranitidine, Cetirizine, Diclofenac, Indomethacin and Mephenamic acid


Status: Completed,
5.

Metabolic Polymorphism Study in Iranian Population


Status: Completed,
6.

Population Pharmacokinetics/Pharmacodynamic Studies of theophylline, digoxin, carbamazepine and methotrxate in Iranian Patients


Status: Completed,

Papers

English

1.

Effect of Food Stimulated Liquids and Thermocycling on the Monomer Elution from a Nanofilled Composite


Authors: , Masumeh Hasani Tabatabaei, Sima Sadrai, Seyed Hossein Bassir, Nadia Veisy and Somaye Dehghan
The Open Dentistry Journal, Vol.7, Year. 2013, Page:62-67,
2.

. Clinical Pharmacokinetics of Oral Versus Sublingual Administration of Tacrolimus in Adult Liver Transplant Recipient


Authors: Zahra Nasiri-Toosi, Simin Dashti-Khavidaki, Sima Sadrai
Exp Clin Transplant , Vol.10, No.6, Year. 2012, Page:586-591,
3.

Genetic Analysis of Clopidogrel Resistance


Authors: Maryam Dehghni, Parinaz Ghadam, Sima Sadrai
Genetics In The 3rd Millennium, Vol.8, No.4, Year. 2011, Page:2393-2401,
4.

Improvement of clavulanic acid production by Streptomyces clavuligerus with peanut derivatives


Authors: Javad Hamedi, Fatemeh Imanparast, Hassan Tirandaz, Behzad Laamerad and Sima Sadrai
Annales of Microbiology, Vol.61, Year. 2011,
5.

Population pharmacokinetics of oral high-dose busulfan in adult patients undergoing hematopoietic stem cell transplantation


Authors: Hadjibabaie M., Rahimian S., Jahangard-Rafsanjani Z., Amini M., Alimoghaddam K., Iravani M., Ghavamzadeh A., Sadrai S
DARU, Vol.19, No.3, Year. 2011, Page:216-223,
6.

Oral lorazepam prevents seizure during high-dose busulfan in children undergoing hematopoietic stem cell transplantation: a prospective study


Authors: Hamidieh AA, Hamedani R, Hadjibabaie M, Amini M, Sadrai S, Ghavamzadeh A
Pediatr Hematol Oncol, Vol.27, No.7, Year. 2010, Page:529-33,
7.

VKORC1 Gene Analysis of some Iranian Sensitive Patients to Warfarin


Authors: Z. Kianmehr, P. Ghadam, S.Sadrai and R. Sharifian
Pakistan Journal of Biological Sciences, Vol.13, No.18, Year. 2010, Page:906-910,
8.

Genetic mechanisms for sensitivity to the anticoagulant Warfarin


Authors: Z. Kianmehr, Parinaz Ghadam, Sima Sadrai, R. Sharifian, Z Maleki
Genetics In The 3rd Millennium, Vol.7, No.2, Year. 2009, Page:1674-1680,
9.

Steady-state pharmacokinetic analysis of vancomycin in Iranian pediatric patients


Authors: T Safarnavadeh ، S Rezaee ، S Dashti-Khavidaki ، H Khalili ، K Daneshjoo ، S Sadrai ،
DARU , Vol.17, No.2, Year. 2009, Page:124-130,
10.

Effects of vitamin E administration on APACHE II Score in ARDS patients


Authors: M Hajimahmoodi ، M Mojtahedzadeh ، N GhaffarNatanzi ، S Sadrai ، N Sadeghi ،
DARU, Vol.17, No.1, Year. 2009, Page:24-28,
11.

VKORC1 Gene analysis in Iranian warfarin resistant patient


Authors: P. Ghadam, F. Sadeghian ,R. Sharifian, S.Sadrai, B. Kazemi and E. Nematipour
Journal of Biological Sciences, Vol.8, No.3, Year. 2008, Page:691-692,
12.

Assaying of warfarin in Iranian warfarin resistance patient Blood by HPLC


Authors: S.Sadrai, P. Ghadam, R. Sharifian and F. Sadeghian
Pakistan Journal of Biological Sciences , Vol.11, No.4, Year. 2008, Page:683-685,
13.

Pharmacokinetic analysis of warfarin in Iranian sensitive patients


Authors: S.Sadrai, P. Ghadam, R. Sharifian, E. Nematipour, Z. Kianmehr and Sh. Shahriari
International Journal of Pharmacology, Vol.4, No.2, Year. 2008, Page:149- 152,
14.

Pharmacokinetic and pharmacodynamic evaluation of metformin HCl 500 mg tablet among healthy volunteers


Authors: Rouini MR, Sadray S, Ardakani Y, Mokhberi M, Sedaghat S
Iranian journal of Diabetes and lipid disorders, Vol.6, No.2, Year. 2006,
15.

Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS


Authors: P. Salari , M. Mojtahedzadeh , A. Najafi, S. Sadrai, K. Bahaadini , M. Moharreri, N. Hadavand and M. Abdollahi
Journal of Clinical Pharmacy and Therapeutics , Vol.30, Year. 2005, Page:139–144,
16.

The relationship between pharmacokinetic variables and pharmacodynamic profiles of bolus versus continuous infusion of furosemide in critically ill patients


Authors: Mojtaba Mojtahedzadeh, Maria Tavakoli Ardakani, Ebrahim Salehifar, Atabak Najafi, Mohammad Reza, Khajavi, Majid Moeini,*Sima Sadray
DARU, Vol.13, No.3, Year. 2005,
17.

Comparison of Carbamazepine Clearance Between Epileptic Patients and Patients with Acute Mania


Authors: AH Mohammadpoor, P Ghaeli,S Sadray,M Noroozian,M Forooghpoor,S Rezaee
Daru, No.12, Year. 2004,
18.

Role of Magnesium Loading Test in Detecting Hypomagnesemia in Critically Ill Patientstes


Authors: Sohrevardi SM.,Mojtahedzadeh M., Sadray S,et al
Medical Journal of the Islamic Republic of Iran, Vol.18, No.1, Year. 2004,
19.

Pharmacokinetics Behavior of Theophylline following PEEP in Critically Ill Patients with Acute Lung Injury


Authors: Hadavand N., Mojtahedzadeh M., Sadray S., Shariat Moharreri R., Shafaghi B., Khajavi MR. and Salari P
Iranian Journal of Pharmaceutical Research, Vol.3, Year. 2004, Page:35-40,
20.

Assessment of Digoxin Serum Concentration in Continuous and Interrupted Digoxin Regimens


Authors: S. Sadray1, S. Namazi2, Kh. Gholami ,M. Eslami, M. Lesanpezeshki, H. Fani
DARU, Vol.11, No.3, Year. 2003, Page:99-105,
21.

Non-linear heteroscedastic regression model for determination of methotrexate in human plasma by high-performance liquid chromatography


Authors: S. Sadray, S. Rezaee and S. Rezakhah
Journal of Chromatography B, Vol.787, Year. 2003, Page:293-302,
22.

Efficacy of urine samples in bioavailability study of ranitidine


Authors: S. Sadray, H. Tajerzadeh, A. Mohajer, A. Mirfazaelian
DARU, Vol.11, No.2, Year. 2003, Page:52-57,
23.

Likelihhod - based diagnostics for influential individuals in nonlinear mixed effect modelling


Authors: S. Sadray, Mats Karlsson, Niclas Jonsson
Pharmaceutical Research, No.8, Year. 1999, Page:1260-1265,
24.

A rapid HPLC determination of theophylline in human serum


Authors: H. Tajerzadeh , S. Sadary
Medical Journal of the Islamic Republic of Iran, Vol.13, No.3, Year. 1999,
25.

Synthesis, Antibacterial and Antifungal Activity of 2-methylsulfonyl-5-(1-methyl-5-nitro-2-imidazolyl)1,3,4-Thiadiazole


Authors: A.Shafiee, M.Anaraki, S.Sadray, F. Kamal
Journal of Sciences Islamic Republic of Iran, Vol.1, No.20, Year. 1990, Page:44-48,
26.

Determination of Theophylline Clearance after Cimetidine Infusionin critically ill patients


Authors: Mojtahedzadeh M., Sadray S., Hadjibabaie M., Fasihi M., Rezaee S
Journal of Infusion Nursing, Vol.26, No.4, Page:234-238,
27.

Population Pharmacokinetics of Theophylline in Iranian Patients


Authors: S. Sadray, H. Tajerzadeh
Daru,

Abstracts and Presentations

English

1.

The impact of VKORC1 genetic polymorphisms in Iranian warfarin sensitive patients with normal CYP2C9


The 15thConference & the 3rd International conference Biology
Location: Tehran-Iran,
Date: August,2008-
Authors: P. Ghadam1, S.Sadrai2, R. Sharifian3, B. Kazemi4, Z.Kianmehr1, F. Yarian1
Type : Abstract, Lecturer,
2.

Pharmacokinetic and pharmacogenetic analysis of warfarin in iranian patients sensitive to warfarin


The 9th Iranian Congress of Biochemistry & the 2nd International congress of biochemistry and Molecular biology
Location: Shiraz-Iran,
Date: Oct 29 ,2007-Nov 1,2007
Authors: Sima Sadrai, Parinaz Ghadam, Ramezanali Sharifian
Type : Abstract, Lecturer,
3.

Principles of Accreditation for Dental Education


4th Intenational Conference of Higher Education & Development in Knowledge Based Society: Towards Enhacing Quality and Relevance
Date: September 7 2007-September 11 200
Authors: Mahgoli HA, Sadrai S
Type : Abstract, Lecturer,
4.

Assessment of Pharmacy Education


4th Intenational Conference of Higher Education & Development in Knowledge Based Society: Towards Enhacing Quality and Relevance
Date: September 7 2007-September 11 200
Authors: Sadrai Sima
Type : Abstract, Lecturer,
5.

Efficacy of urine samples in bioavailability study of ceterizine, a drug with multiple peak phenomena in plasma and urine sample


18th Iranian Congress of Physiology and Pharmacology
Location: Mashhad- Iran,
Date: August 26 2007 -August 30 2007
Authors: Sadrai S, Fahimi S, Toliyat T, Hamidi P, Rezaee S
Type : Abstract, Lecturer,
6.

Pharmacodynamic and electrolyte changes after administration of bolus versus continuous infusion of furesemide in critically ill


10th Iranian Pharmaceutical Sciences Conference (IPSC)
Date: 21 August 2006-24 August 2006
Authors: Tavakoli Ardakani M, Mojtahedzadeh M, Sadrai S
Type : Abstract, Lecturer,
7.

Evaluation and importance of double-peak phenomenon in the bioequivalency of gliclazide 80 mg tablets


10th Iranian Pharmaceutical Sciences Conference (IPSC)
Date: 21 August 2006-24 August 2006
Authors: Sadray S, Safari S, Farahani M, Rouini MR
Type : Abstract, Lecturer,
8.

Comparison of carbamazepine clearance between epileptic patients and patients with acute mania


10th Iranian Pharmaceutical Sciences Conference (IPSC)
Date: 21 August 2006-24 August 2006
Authors: Mohammadpoor AH, Ghaeli P, Sadray S, Forooghipoor M, Noroozian M, Rezaee S
Type : Abstract, Lecturer,
9.

Determination and quantification of cetirizine in human plasma by high performance liquid chromatography


10th Iranian Pharmaceutical Sciences Conference (IPSC)
Date: 21 August 2006 -24 August 2006
Authors: Sadray S, Lavasani H, Ariapoor M
Type : Abstract, Lecturer,
10.

Population Pharmacokinetics Comparison of Carbamazepine Clearance between Epileptic and Acutely Manic Patients


5th International Symposium on Measurement and Kinetics of In Vivo Drug Effects
Location: Noorwijkerhout, The Netherlands,
Date: April 26, 2006-April 29, 2006
Authors: Sadrai S, Mohammadpoor AH, Ghaeli P, Forooghipoor M, Noroozian M
Type : Abstract, Lecturer,
11.

IVIVC of controlled release diclofenac capsules with Voltaren,considering multiple perak phenomena


2nd EUFEPS Conference ,Evaluation of Drug Delivery Systems
Location: France,
Date: 2 Dec 2005- 6 Dec 2005
Authors: Dr Sima Sadray, Leila Esmaili
Type : Abstract, Lecturer,
1.

Computer Knowledge:


Fortran, Splus, SPSS,NonMem, Winnonlin, WINNONMIX, MONOLIX, etc 

2.

Skills:


Good command of analytical instruments especially HPLC and computer soft wares especially NONMEM, SAS, EMACS, SPLUS. 

Experie, as homeopathy and spiritual healing.

1. Pharmcokinetics, Modelling, PKPD modelling, Homeopathy, Complementary Medicine
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