Postdoctoral fellowship

Project title: Homology modeling of a glucosidase enzyme

Under supervision of Professor Hans-Dieter Hoeltje

Ph.D

Pharm D

Persian

French -close to native

English-written, read, spoken

German -Zertifikat Deutsch, grade: 1

Selected as best 2004 Biochemistry Ph.D. candidate of IBB

Ranked second between fellow students of the Pharm.D. program

Assistant Professor

Associate Professor

Molecular modeling and in vitro study on proposed lipase inhibitors

Study on the effects of some phenol and purine compounds on alpha-amylase activity using a direct kinetic assay

Comparative study of organic solvents effect on insulin aggregation

Biotechnology, M.Sc. Thesis

Study on the effect of natural compounds on amyloid formation of insulin.

Chemical modification of the lysine residue of bovine insulin and studying modified protein structure and aggregation in vitro

Molecular modeling studies on bacterial acetate kinase: studying the active site and design of inhibitors

Study on the inhibitory effect of polyphenolic compounds on alpha-amylase enzymes from Aspergillus oryzae, Sus scrofa and human

Investigation of the effect of several natural compounds on the activity of alpha amylase and level of blood sugar in diabetic

Advisor for 18 M.Sc. theses (Biochemistry,Biophysics) between

A comparative study on amyloid fibril formation in apo and holo bovine carbonic anhydrase II

Induction and characterization of intermediate structures in glutamate dehydrogenase leading to its aggregation.

duction of amyloid aggregation of bovine alpha-chymotrypsin and biochemical and biophysical characterization of its intermediate

Complexation of nicotinic acid with first generation poly (amidoamine) dendrimers: A microscopic view from density functional theory

Therapeutic protein deimmunization by T‐cell epitope removal: antigen‐specific immune responses in vitro and in vivo

Investigation of thymol effect on learning and memory impairment induced by intrahippocampal injection of amyloid beta peptide in high fat diet-fed rats

Turmeric effect on subcutaneous insulin-induced amyloid mass: an in vivo study

Characterization of surface binding sites in glycoside hydrolases: A computational study

Structure and function of anhydride-modified forms of human insulin: In silico, in vitro and in vivo studies

Amyloid-like aggregates formation by bovine apo-carbonic anhydrase in various alcohols: A comparative study

Bis (indolyl) phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme

Effect of trans-chalcone on atheroma plaque formation, liver fibrosis and adiponectin gene expression in cholesterol-fed NMRI mice

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Acarbose and the thermal aggregation of Bacillus amyloliquefaciens alpha‐amylase (BAA): protective effect of an inhibitor

Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

Rational design of stable and functional hirudin III mutants with lower antigenicity

Bacterial expression and characterization of an active recombinant lipase A from Serratia marcescens with truncated C-terminal region

Acarbose versus trans-chalcone : comparing the effect of two glycosidase inhibitors on obese mice

Inhibition of amyloid fibril formation and cytotoxicity by a chemical analog of curcumin as a stable inhibitor

UV spectrophotometric determination and validation of hydroquinone in liposome

Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats : report on memory impairment and formation of amyloid plaques

. Segregation of a novel homozygous 6 nucleotide deletion in GLUT2 gene in a Fanconi-Bickel syndrome family.

Effect of neohesperidin dihydrochalcone on the activity and stability of alpha-amylase: a comparative study on bacterial, fungal, and mammalian enzymes

Structural stability of myoglobin and glycomyoglobin: A comparative molecular dynamics simulation study

Thioflavin T effect in diabetic Wistar rats: Reporting the antihyperglycemic property of an amyloid probing dye

Interaction of Aβ(25-35) Fibrillation Products with Mitochondria: Effect of Small-Molecule Natural Products

A novel missense mutation in oncostatin m receptor Beta causing primary localized cutaneous amyloidosis

Applications of molecular modeling in endocrinology

A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS)

A molecular modeling study on full length insulin: insight into initial events of amyloid formation

Generating local amyloidosis in mice by subcutaneous injection of human insulin amyloid

Ectopic Cushing syndrome associated with thymic carcinoid tumor as the first presentation of MEN1 syndrome-report of a family with MEN1 gene mutation

Production of insulin amyloid nanofibrils in organic solvents: a comparative study

Silymarin effect on amyloid ß plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model

Amyloid formation and inhibition of an all-beta protein: a study on fungal polygalacturonase

Indole and trans–chalcone attenuate amyloid beta plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds

Targeting acetate kinase: inhibitors as potential bacteriostatics

How curcumin affords effective protection against amyloid fibrillation in insulin

Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha- amylase as an allosteric effector

Reflection on design and testing of pancreatic alpha-amylase inhibitors: an in silico comparison between rat and rabbit enzyme models

Heme binding site in apomyoglobin may be effectively targeted with small molecules to control aggregation

Maternal zinc intake of Wistar rats has a protective effect in the alloxan-induced diabetic offspring

Xanthine derivatives as activators of alpha-amylase: Hypothesis on a link with the hyperglycemia induced by caffeine

Response surface methodology for optimizing the bovine serum albumin fibrillation

Thermal disaggregation of type B yeast hexokinase by indole derivatives: a mechanistic study

Amyloid fibrillation in native and chemically-modified forms of carbonic anhydrase II: Role of surface hydrophobicity.

Detection of KCNJ11 Gene Mutations in a Family with Neonatal Diabetes: Implications for Therapeutic Management of Family Members with Long-Standing Disease

Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase

Novel mutations of wolframin: a report with a look at the protein structure

new frameshift MEN1 gene mutation associated with familial malignant insulinomas.

-Effects of Sucrose and Trehalose on Stability, Kinetic Properties, and Thermal Aggregation of Firefly Luciferase

Prevention of thermal aggregation of an allosteric protein by small molecules: Some mechanistic insights

Benzofuranone derivatives as effective small molecules related to insulin amyloid fibrillation: a structure-function study

-Immobilization of acetylcholinesterase in nanofibrous PVA/BSA membranes by electrospinning

Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus.

Protein-protein interactions leading to aggregation: perspectives on mechanism,significance and control

Chemical modification of lysine residues in lysozyme may dramatically influence its amyloid fibrillation

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats

Amyloidogenic potential of alpha-chymotrypsin in different conformational states

Thermal aggregation of a model allosteric protein in different conformational states.

Mutation screening of VHL gene in a family with malignant bilateral pheochromocytoma: from isolated familial pheochromocytoma to von Hippel-Lindau disease

Thermal aggregation of α-chymotrypsin: Role of hydrophobic and electrostatic interactions

Thermally induced changes in the structure and activity of yeast hexokinase B

-Role of electrostatic interactions in 2,2,2-trifluoroethanol-induced structural changes and aggregation of α-chymotrypsin

Effect of polyamines on the structure, thermal stability and 2,2,2-trifluoroethanol-induced aggregation of α-chymotrypsin

Inhibition of amyloid fibrillation of lysozyme by indole derivatives : possible mechanism of action.

Thermostabilization of Bacillus amyloliquefaciens alpha-amylase by chemical crosslinking

-Chemical modification of lysine residues in Bacillus licheniformis alpha-amylase: conversion of an endo- to an exo-type enzyme.

Interaction of an intermediate structure of Bacillus subtilis alpha-amylase with alkyl-substituted sepharose 4B: a model of membrane translocation

Chemical modification of bacterial alpha-amylases: changes in tertiary structures and the effect of additional calcium

Acylation of LYS residues prevents thermal aggregation of glutamate dehydrogenase

Prevention of thermal aggregation of glutamate dehydrogenase by polyamines

TFE-induced aggregation of alpha-chymotrypsin:involvement of hydrophobic and electrostatic interactions

Heat-induced aggregation of a-chymotrypsin: role of hydrophobic and electrostatic Interactions

-Effect of amino acids on thermal aggregation of glutamate dehydrogenase

Chemical modification of Lys residues prevents TFE-induced aggregation of alpha-chymotrypsin

Inhibition of amyloid fibrillation of lysozyme by indole derivatives

The role of phosphate in thermal aggregation of yeast hexokinase II

Modification of lysine residues in lysozyme: Effects on amyloid fibrillation

Induction of amyloid fibril formation by alpha-chymotrypsin by two different methods

Aggregation of glutamate dehydrogenase: role of allosteric effectors. Sabbaghian M.,

Prevention of thermal aggregation of alpha-chymotrypsin by acetylation of its lysine residues

Homology modelling of human Maltase enzyme and in silico characterization of its active site

An in silico study on the inhibitor selectivity of Cathepsin G

Modification of alpha-Chymotrypsin with Citraconic Anhydride: Changes in Structure and Stability

Investigation of Conformational Change of Glutamate Dehydrogenase in the Presence of TFE

Dramatic Enhancement of Lysozyme Fibrillogenesis by ATP

Formation of small soluble aggregates may be responsible for irreversible thermal denaturation of yeast hexokinase B

Thermal aggregation of Bacillus amyloliquefaciens alpha-amylase: effect of amino acids

Inhibitors of insulin amyloid formation: an in silico study

Flavonoids as potential antihyperglycemics: an in silico study of their alpha-amylase inhibitory mode.

Molecular modelling studies on alpha-glucosidase interaction with inhibitors

Curcumin inhibits mammalian alpha-amylase

Thioflavin T may influence fibrillation of proteins of different structural properties

Synchronize fluorescence study of interaction between human lactoferrin as a carrier and lomefloxacin

Investigation on the interaction between two different drugs (lomefloxacin and colchicines) and human serum albumin: A spectrosc

Targeting acetate kinase: Inhibitors as potential bacteriostatics.Asgari S

-Design of new alpha-glucosidase inhibitors based on molecular modeling studies

Molecular modeling studies on cholesterol esterase inhibitors: proposition of new ligands , and insight into possible additional

Proposal Of Novel Nad+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Inhibitors Based On A Molecular Modeling Study.

Molecular Modeling Study on Palmitate Binding Site in Echovirus Coat Protein: Proposing an Antiviral Target

Thioflavin as a potential antidiabetic lead compound

Journal of Diabetes and Metabolic Disorders

Section Editor (Interdisciplinary Medicine)

Iran Society of Biophysical Chemistry

Iran Bioinformatics Society

Iran Endocrine Society