Tehran University of Medical Sciences
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Ahmad Ameri

Duane's retraction syndrome & karyotypic abnormalities


Authors: A. K-Jafari, S.-M. Hoshmand, I. Ahadzadeghan, F. Anvari, Ahmad Ameri, mohammad reza Akbari, Mohammad Taher Rajabi
International Journal of Ophthalmology, Vol.8, No.9, 2008,Page:1747-1748

• Aim: To evaluate chromosome 8 abnormalities in Duane's retraction syndrome (DRS) type I.

• Methods: We evaluated chromosome 8 abnormalities in 29 consecutive cases of DRS type I. DNA was isolated from the peripheral leukocytes of patients using a genomic DNA extraction kit, then D8S553 and D8S1797 markers used for polymerase chain reaction (PCR).

• Results: None of the cases were positive for the two markers D8S553 and D8S1797 on chromosome 8 which were tested in our study.

• Conclusion: The possible cause of this finding is that DRS in our patients is more commonly sporadic rather than familial. We recommend study with more cases, other markers, and different chromosomes.