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Ghasemali Khorasani

Botulinum Toxin Type A Effects on the Treatment of Keloid Lesions: Comparison of Intralesional Two Different Doses


Authors: Afshin Fathi, Qassem Ali Khorasani, Siamak Farokh Forghani, Ahmad Reza Taheri
Keywords: Keywords: Botulinum Toxin Type A, Keloid, Vancouver Scar Scales.
International Journal of Medical Research Professionals, Vol.3, No.2, 2017,Page:306-11

Background: Keloid is a lesion that creates from the excessive restoration of the scar and has beauty and functional complications for patient and changes their quality of life. Today, varieties of methods are used but because of lesion recurrence, patients’ problems last. In this study, the two different doses of botulinum toxin type A, impact on the treatment of keloid lesion has been investigated.
Methods: In this double blind clinical trial, 43 patients with keloid lesions were interfered from August 2014 to May 2016. Patients were randomly divided into two groups. Each patient received BTX-A with concentration 200 units per ml and dose of 10 or 20 units per cubic centimeter lesion in a part of the lesion. In another part of the lesion, normal saline was injected with the same volume. Injections have been done monthly to three times. Patients were evaluated 9 months after the last injection, according to the Vancouver scar scales and Results were analyzed in both groups.
Results: The average Index of pigmentation in the first intervention group reduced to 0.64 and in the second intervention group, it reduced to 0.74 (P <0.01). Pliability of lesions had a statistical significant reduction than before in both
groups of intervention, but, but there was no significant difference in height index of lesion (P = 0.72).
Conclusion: Injection of botulinum toxin type A in keloid lesions, not as a stand-alone method, but in ancillary of other therapy procedures such as surgery, can be useful in the management of symptoms caused by keloid lesions.